The detune property of the AudioBufferSourceNode interface is a k-rate AudioParam representing detuning of oscillation in cents. 
  For example, values of +100 and -100 detune the source up or down by one semitone, while +1200 and -1200 detune it up or down by one octave. 
 
 A k-rate AudioParam whose value indicates the detuning of oscillation in cents. 
   Note: Though the AudioParam returned is read-only, the value it represents is not. 
  
 
const audioCtx = new AudioContext();
const channelCount = 2;
const frameCount = audioCtx.sampleRate * 2.0; 
const myArrayBuffer = audioCtx.createBuffer(
  channelCount,
  frameCount,
  audioCtx.sampleRate,
);
for (let channel = 0; channel < channelCount; channel++) {
  const nowBuffering = myArrayBuffer.getChannelData(channel);
  for (let i = 0; i < frameCount; i++) {
    nowBuffering[i] = Math.random() * 2 - 1;
  }
}
const source = audioCtx.createBufferSource();
source.buffer = myArrayBuffer;
source.connect(audioCtx.destination);
source.detune.value = 100; 
source.start();