The colorMaskiOES() method of the OES_draw_buffers_indexed WebGL extension sets which color components to enable or to disable when drawing or rendering for a particular draw buffer. It's the indexed version of WebGL 1's WebGLRenderingContext.colorMask() method.
 
colorMaskiOES(buf, r, g, b, a)
  
You can set the color masks for the gl.DRAW_BUFFER0 and gl.DRAW_BUFFER1 draw buffers like this:
 
const ext = gl.getExtension("OES_draw_buffers_indexed");
ext.colorMaskiOES(0, 1, 0, 0, 0);
ext.colorMaskiOES(1, 0, 1, 0, 0);
  To get the color masks for the gl.DRAW_BUFFER0 and gl.DRAW_BUFFER1 draw buffers, query the COLOR_WRITEMASK constant using WebGL2RenderingContext.getIndexedParameter():
 
gl.getIndexedParameter(gl.COLOR_WRITEMASK, 0);
gl.getIndexedParameter(gl.COLOR_WRITEMASK, 1);